Contact Information
If you think that you might be eligible for this study or for more information, please contact:
Dr. Karen Graham, 919-966-7088

The purpose of this study is to determine if amantadine added very soon after starting olanzapine therapy can prevent weight gain due to olanzapine, in first episode subjects.

Inclusion:

•  ages 18-45, all races and genders

•  meets DSM IV criteria for a psychotic disorder.

•  monotherapy with olanzapine is planned or has recently been started by the subject's treating psychiatrist

•  less than 8 weeks of antipsychotic therapy (other than olanzapine)

•  less than 12 weeks of treatment with olanzapine

•  able to consent

Exclusion:

•  current substance dependence or heavy substance use

•  requires ongoing treatment with a medication known to affect weight (to be reviewed by study   

physicians)

•  suicidal or homicidal

•  Female patients who are either pregnant or nursing.