Psychiatry - UNC School of Medicine
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Brain Development in Fragile X
A Longitudinal MRI Study of Brain Development in Fragile X Syndrome: A Collaborative Research Project Between the University of North Carolina at Chapel Hill, Stanford University, and Duke University Medical Center
The goal of the current research project is to increase our understanding of normal brain development and how the brain develops in children with Fragile X Syndrome, developmental delay and typically developing children. This new information will provide clues about how brain development may differ for individuals with Fragile X and related disorders.
Participants in each group will receive developmental and behavioral assessments and an MRI scan of the brain between 18-42 months of age. A similar assessment, including a second MRI, will be conducted 24 months later when the child is between 42-66 months of age. Parent and family assessments will also be conducted as part of this study. Participants in the Fragile X and Developmentally Delayed group may also receive genetic testing to confirm or exclude a diagnosis of Fragile X. These participants may also receive conscious sedation for the MRI scan. Participants will receive compensation of up to $400 (depending on level of assessment) and will be reimbursed for travel and related expenses. Assessments associated with the project are provided at no cost to the family, and participants will be given any new information gained upon completion of the study.
UNC IRB# 02-PSYCH-380
Duke IRB# 4124-02-9