| Education:
B.S., Pharmacy: Butler University
M.S., Pharmacology; Minor, Medicinal
Chemistry: Butler University
Ph.D., Pharmacology; Minor, Physiology:
University of Tennessee
Summary
Statement:
The Neuropharmacology laboratory,
which Dr. Breese directs, has as a
primary mission to understand the
persistent effects of lesions to neural
systems and the neural consequences
of chronic administration of drugs.
Currently, the laboratory is investigating
the neurochemical and neuroanatomical
basis of the sensitization of anxiety-like
behavior induced by repeated withdrawals
from 3 cycles of chronic ethanol exposure.
Furthermore, there is an effort to
understand the basis of stress substituting
for withdrawals from chronic ethanol
to sensitize withdrawal-induced deficits
in anxiety and to increase voluntary
drinking. In rats with dopamine-containing
neurons destroyed during development
to model the dopamine loss in Lesch-Nyhan
disease, work continues to understand
the basis of priming of the sensitivity
of responses to D1-dopamine agonists
in rats lesioned as neonates by exploring
chronic changes in transcription factors.
Since the neonate-lesioned rat may
also serve as a model of NMDA hypofunction
in schizophrenia because of its supersensitivity
to repeated treatment with NMDA antagonists,
the neurochemical and neuroanatomical
basis of this behavioral sensitization
to NMDA antagonists is sought.
Representative
Publications:
1. Breese GR, Baumeister AA, McCown
TJ, Emerick SG, Frye GD, Crotty K,
Mueller RA: Behavioral differences
between neonatal and young adult 6-hydroxydopamine-treated
rats to dopamine agonists: Relevance
to neurological symptoms in clinical
syndromes with reduced brain dopamine.
J Pharmacol Exp Ther 231:343-354,
1984.
2. Criswell,
H.E., Mueller, R.A. and Breese, G.R.:
Long-term D1-dopamine receptor sensitization
in neonatal-6-OHDA-lesioned rats is
blocked by an NMDA antagonist. Brain
Res. 512:284-290, 1990.
3. Breese, G.R.,
Knapp, D.J., and Moy, S.S., Integrative
role for serotonergic and gluatmatergic
receptor mechanisms in the action
of NMDA antagonists: Potential relationships
to acute and chronic actions of antipsychotic
drugs. Neuroscience and Biobehavioral
Reviews 26:441-455, 2002
4. Overstreet,
D.H., Knapp, D.J., and Breese, G.R.
Accentuated decrease in social interaction
in rats subjected to multiple alcohol
withdrawals. Alcoholism: Clin. Exp.
Res. 26:1259-1268, 2002
5. Moy, S.S.
and Breese, G.R. Phencylidine supersensitivity
in rats with neonatal dopamine loss.
Psychopharmacology 161:255-262, 2002.
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